Cell migration mechanisms largely depend on cell type and the guiding cellular environment. Thus, cells acquire specific migratory phenotypes to migrate efficiently through tissues and adapt to their microenvironment. Motile cells are polarized, and the actin cytoskeleton is a key modulator of cell polarity and pseudopods whose stabilization determines the directionality of the movement.

Q-Phase defines the pattern of cell polarity through the assessment of the morphological profile of migratory cells together with the measurement of their core and peripheral dry mass distribution.

Deregulation of cell migration is involved in cancer progression and metastatic development. Thus it constitutes a major research topic of interest for decades already.

In this context, the LiveCodim can represent the perfect choice to dynamically image the actin cytoskeleton and visualize the specific structures involved in cell migration and invasion in superresolution, such as actin stress fibers, filopodia, lamellipodia, endosomes, etc.