Telight

Telight

Drug toxicity

The rapid advancement of pharmaceutical therapeutics and biomaterials opened the gate for studying various therapeutic modalities for diseases.

Accurate quantification of drug effects on cells or tissues is crucial for determining the safety, effectivity, and toxicity of drugs or biomaterials.

Q-Phase is a fast and versatile tool for long-term live-cell imaging, ideal for detecting the influence and toxicity of tested drugs or biomaterials. It allows for real-time quantification of multiple cellular parameters within a single experiment.

Due to the label-free technology and the extremely low phototoxicity, the tested agent represents the major variable that affects the behavior of the cell during the experiment.

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88 hours cultivation of prostate cancer cell line PC3 with mTOR and AKT inhibitors showing that cells with higher cell mass are more sensitive to treatment combination

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Doxorubicin uptake in prostate cancer cells LNCaP.

Merged QPI and fluorescence

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Apodox uptake in human breast cancer cell line MDA MB 231

Magnification 20x

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APODOX directed prostate-specific membrane antigen induced cell death in LNCap cell line

Merged QPI and fluorescence | Magnification 10x

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APODOX directed prostate-specific membrane antigen induced cell death in LNCap cell line

Merged QPI and fluorescence | Magnification 20x

LiveCodim is the perfect tool for high-resolution visualization of functional aspects of newly developed drugs. The high resolution allows for observing of the drug targeting – from entry within the cells to its trafficking – in a living sample, and thus elucidate fundamental mechanisms of drug activity within cells.

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Publications

L. Eyer, et al.

Broad-Spectrum Antiviral Activity of 3’-Deoxy-3’-Fluoroadenosine against Emerging Flaviviruses

M. Fojtů, et al.

2D Germanane Derivative as a Vector for Overcoming Doxorubicin Resistance in Cancer Cells

M. Štefančík, et al.

Ni and TiO2 nanoparticles cause adhesion and cytoskeletal changes in human osteoblasts

Products

Telight Q-Phase

Telight Q-Phase

Discover QPI!

Q-Phase is a patented type of holographic microscope with high detection sensitivity

Q-Phase represents an ideal solution for experts who desire precise automated segmentation of individual cells for subsequent data analysis. Q-Phase easily transforms cell features and dynamics into numerical data ideal for comparisons, correlations, and more detailed statistics.

Telight LiveCodim

Telight LiveCodim

From conventional to super-resolution microscopy

LiveCodim is a universal, super-resolution imaging platform, designed to interface with any standard fluorescence microscope. It is the solution for live imaging with high resolution and low phototoxicity.