Extracellular matrix
Observation and analysis of cell behavior in a stromal extracellular matrix (ECM), for example, collagen and matrigel, are essential for a full understanding of many biological processes. ECM mimics the structure and composition of the in vivo environment and largely influences the cellular properties, particularly in adhesion, migration, and differentiation.
Thanks to the coherence-gating effect which is a special feature enabled by Q-Phase to effectively suppress the light that is scattered by the environment in defocused planes and to only use unscattered light for imaging. Therefore, the QPI image quality is not impaired by the presence of the disturbing matrix.
Publications
Quantitative phase imaging unravels new insight into dynamics of mesenchymal and amoeboid cancer cell invasion
Coherence-controlled holographic microscopy enabled recognition of necrosis as the mechanism of cancer cells death after exposure to cytopathic turbid emulsion
Coherence-controlled holographic microscopy in diffuse media
Quantitative phase imaging through scattering media by means of coherence-controlled holographic microscope
Products
Telight Q-Phase
Discover QPI!
Q-Phase is a patented type of holographic microscope with high detection sensitivity
Q-Phase represents an ideal solution for experts who desire precise automated segmentation of individual cells for subsequent data analysis. Q-Phase easily transforms cell features and dynamics into numerical data ideal for comparisons, correlations, and more detailed statistics.