Extracellular matrix
Observation and analysis of cells in a stromal extracellular matrix (ECM), for example, collagen and matrigel, are essential for a full understanding of cell behavior. ECM mimics the structure and composition of the in vivo environment and affects many cellular properties, particularly adhesion, migration, and differentiation.
Thanks to the coherence-gating effect, a unique feature enabled by Telight Q-Phase, the QPI image quality is not impaired by the presence of the disturbing matrix. Therefore, the Q-Phase allows precise cell observation and analysis in scattering media.
Publications
Quantitative phase imaging unravels new insight into dynamics of mesenchymal and amoeboid cancer cell invasion
Coherence-controlled holographic microscopy enabled recognition of necrosis as the mechanism of cancer cells death after exposure to cytopathic turbid emulsion
Coherence-controlled holographic microscopy in diffuse media
Quantitative phase imaging through scattering media by means of coherence-controlled holographic microscope
Products
Telight Q-Phase
Quantitative Phase Imaging
Q-Phase is a patented holographic microscope with high detection sensitivity.
Q-Phase is an ideal solution for experts who desire precise automated segmentation of individual cells for subsequent data analysis. Q-Phase quickly transforms cell features and dynamics into numerical data suitable for comparisons, correlations, and more detailed statistics.