Cell-cell interactions
Cells interact with each other and with the environment in a very precise and regulated manner. The interactions play a crucial role in many cellular processes and ensure the integrity of tissue structure.
Cell-to-cell interaction forms communication channels for transmitting signals or synchronizing the response, for example in muscle contraction. However, loss of the interactions can result in unfavorable conditions for cell growth and ultimately leads to cancer.
Q-Phase opens the gates for discovering how cells interact together to prevent cell death in unfavorable cultivation conditions.
Moreover, it provides visualization of contact inhibition disruption and its consequences for the development of uncontrolled cell proliferation, tumor formation, and metastasis.
LiveCodim super-resolution fluorescence microscopy is a perfect tool for studying mechanisms of cell-cell interactions such as membrane receptors dynamics and clusterization, actin assembly, dynamics at contact zones, or activation of specific contact-induced signaling pathways.
Publications
J. Balvan, et al.
Oxidative Stress Resistance in Metastatic Prostate Cancer: Renewal by Self-Eating
The adhesion of normal human dermal fibroblasts to the cyclopropylamine plasma polymers studied by holographic microscopy
Ni and TiO2 nanoparticles cause adhesion and cytoskeletal changes in human osteoblasts
Products
Telight Q-Phase
Quantitative Phase Imaging
Q-Phase is a patented holographic microscope with high detection sensitivity, designed for gentle live-cell imaging.
Q-Phase is an ideal solution for experts who desire precise automated segmentation of individual cells for subsequent data analysis. Q-Phase quickly transforms cell features and dynamics into numerical data suitable for comparisons, correlations, and more detailed statistics.
Telight LiveCodim
From conventional to super-resolution microscopy
LiveCodim is a universal, super-resolution imaging platform designed to interface with any standard fluorescence microscope. It is the solution for live-cell imaging with high resolution and low phototoxicity.