Cell-cell interactions
Cells interact with each other and with the environment in a very precise and regulated fashion which plays a crucial role in many cellular processes and ensures the integrity of tissue structure.
Cell-to-cell interaction forms communication channels between cells for transmitting signals or synchronizing the response, for example as in cardiac muscle contraction. However, loss of cell-to-cell interactions can result in uncontrollable cell growth and cancer.
Q-Phase opens the gates for discovering how cells interact together in order to prevent cell death in unfavorable cultivation conditions.
Moreover, it provides visualization of the effect of contact inhibition disruption and its consequences for the development of uncontrolled growth or proliferation, tumor formation, and metastasis.
LiveCodim super-resolution fluorescence microscopy is a perfect tool for studying mechanisms of cell-cell interactions such as membrane receptors dynamics and clusterization, actin assembly, dynamics at contact zones, or activation of specific contact-induced signaling pathways.
Publications
J. Balvan, et al.
Oxidative Stress Resistance in Metastatic Prostate Cancer: Renewal by Self-Eating
The adhesion of normal human dermal fibroblasts to the cyclopropylamine plasma polymers studied by holographic microscopy
Ni and TiO2 nanoparticles cause adhesion and cytoskeletal changes in human osteoblasts
Products
Telight Q-Phase
Discover QPI!
Q-Phase is a patented type of holographic microscope with high detection sensitivity
Q-Phase represents an ideal solution for experts who desire precise automated segmentation of individual cells for subsequent data analysis. Q-Phase easily transforms cell features and dynamics into numerical data ideal for comparisons, correlations, and more detailed statistics.
Telight LiveCodim
From conventional to super-resolution microscopy
LiveCodim is a universal, super-resolution imaging platform, designed to interface with any standard fluorescence microscope. It is the solution for live imaging with high resolution and low phototoxicity.