Telight

Telight

Cell-cell interactions

Cells interact with each other and with the environment in a very precise and regulated fashion which plays a crucial role in many cellular processes and ensures the integrity of tissue structure.

Cell-to-cell interaction forms communication channels between cells for transmitting signals or synchronizing the response, for example as in cardiac muscle contraction. However, loss of cell-to-cell interactions can result in uncontrollable cell growth and cancer.

Q-Phase opens the gates for discovering how cells interact together in order to prevent cell death in unfavorable cultivation conditions.

Moreover, it provides visualization of the effect of contact inhibition disruption and its consequences for the development of uncontrolled growth or proliferation, tumor formation, and metastasis.

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Time-lapse QPI images: (A) Entosis, (B) Cell fusion with cannibalism, (C) Cannibalism without fusion, (D) Oncosis, (E) Reverse oncosis.

Balvan J, et al. (2015) Oxidative Stress Resistance in Metastatic Prostate Cancer: Renewal by Self-Eating. PLoS ONE 10(12): e0145016.

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Prostate cancer cell culture PC3 treated with Plumbagin showing apoptosis, necrosis, and entosis at 10x magnification.

Balvan J, et al. (2015) Oxidative Stress Resistance in Metastatic Prostate Cancer: Renewal by Self-Eating. PLoS ONE 10(12): e0145016.

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PC3 prostate cancer cell shows active ingestion of another cancer cell in a phenomenon called cannibalism

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Movements of subcellular particles along cell processes

LiveCodim super-resolution fluorescence microscopy is a perfect tool for studying mechanisms of cell-cell interactions such as membrane receptors dynamics and clusterization, actin assembly, dynamics at contact zones, or activation of specific contact-induced signaling pathways.

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COS-7 cells cytoskeleton | Actin cytoskeleton is visualized using Sir-Actin marker

Institut Jacques Monod, Imagoseine imaging facility (CNRS UMR7592 and Université de Paris, France)

Products

Telight Q-Phase

Telight Q-Phase

Discover QPI!

Q-Phase is a patented type of holographic microscope with high detection sensitivity

Q-Phase represents an ideal solution for experts who desire precise automated segmentation of individual cells for subsequent data analysis. Q-Phase easily transforms cell features and dynamics into numerical data ideal for comparisons, correlations, and more detailed statistics.

Telight LiveCodim

Telight LiveCodim

From conventional to super-resolution microscopy

LiveCodim is a universal, super-resolution imaging platform, designed to interface with any standard fluorescence microscope. It is the solution for live imaging with high resolution and low phototoxicity.