Telight

Telight

Cancer research

Cancer is an incredibly diverse disease that can arise in different organs and tissues. This diversity is not limited to different tumor types but cells within the same tumor can also vary.

Tumor heterogeneity represents a major medical challenge that requires innovative methods for understanding the role of each distinctive cell population in promoting tumor growth, resistance, and progression.

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Q-Phase

A comprehensive tool to investigate individual cells within a tumor is essential. Q-Phase provides a new opportunity that enables researchers to interpret multiple cellular parameters in real-time including cell morphology profiling, cell dynamics, and cell dry mass.

Live-cell imaging using Q-Phase allows for automated and precise segmentation of cells outlines with subsequent credible statistics and correlations. Therefore, assessment of cell cycles, cell death, and cell migration can be closely achieved in a single experiment.

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Phagocytic activity of human ovarian cancer cell A2780

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Human ovarian cancer cell A2780 in culture

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PC3 prostate cancer cells

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Human ovarian cancer cells (A2780) in culture showing the formation of Polyploid giant cancer cell.

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Autophagy detection in human ovarian cancer cell A2780.

Autophagic vacuoles stained with Cyto-ID®, nuclei with Hoechst 33342 | Magnification 20x

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Primary culture of head and neck squamous cell carcinoma

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Primary culture of head and neck squamous cell carcinoma

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Vacuoles in malignant melanoma cells

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Two days of metastatic prostate cancer cells PC3 in culture

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LiveCodim

During the last decades, microscopy became a weapon of choice to elucidate cancer-cell biology processes such as the steps and development of metastasis.

The LiveCodim module is of interest in this context as it provides new visualization of living cancer cells in high resolution. For example, LiveCodim can bring new insights into the visualization of mitochondria, cytoskeleton, nuclei dynamic, vesicle trafficking, etc.

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COS-7 cells cytoskeleton | Actin cytoskeleton is visualized using Sir-Actin marker

Institut Jacques Monod, Imagoseine imaging facility (CNRS UMR7592 and Université de Paris, France)

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Focal adhesions in MDCK cells | Marker: Vinculin | Vinculin is a membrane-cytoskeletal protein i that is involved in linkage of integrin to the actin cytoskeleton

The MDCK cells expressing fluorescent Vinculin were a generous gift of the Nicolas Borghi team at the Jacques Monod institute: “Mechanotransduction: from cell surface to nucleus”

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Microtubule array on HELA cells | Marker: Anti Beta-tubulin Immuno-labelling with Alexa-488 coupled secondary antibody

Institut Jacques Monod, Imagoseine imaging facility (CNRS UMR7592 and Université de Paris, France)

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Mitochondrial dynamics in MDCK cells | Marker: Mitotracker-Orange | Mitochondria movements are visualized with 1 image every 5 seconds

Institut Jacques Monod, Imagoseine imaging facility (CNRS UMR7592 and Université de Paris, France)

Products

Telight Q-Phase

Telight Q-Phase

Discover QPI!

Q-Phase is a patented type of holographic microscope with high detection sensitivity

Q-Phase represents an ideal solution for experts who desire precise automated segmentation of individual cells for subsequent data analysis. Q-Phase easily transforms cell features and dynamics into numerical data ideal for comparisons, correlations, and more detailed statistics.

Telight LiveCodim

Telight LiveCodim

From conventional to super-resolution microscopy

LiveCodim is a universal, super-resolution imaging platform, designed to interface with any standard fluorescence microscope. It is the solution for live imaging with high resolution and low phototoxicity.